ea0065op6.2 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019
Bollington Mark
, Mistry Anisha
, Solomou Antonia
, Barry Sayka
, Begalli Federica
, Vignola Maria
, Lim Chung Thong
, Herincs Maria
, Roncaroli Federico
, Gaston-Massuet Carles
, Korbonits Marta
Introduction: AIP mutations are responsible for 15-30% of cases of familial isolated pituitary adenomas. The pathophysiology that drives this AIP-related pituitary tumorigenesis is not fully understood. We developed a pituitary-specific Aip knockout (KO) mouse model, which mostly recapitulates the human phenotype.Aims: To performed comparative gene expression analysis of Aip-KO mouse pituitary tumours and AIP mutation positive ...